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Beilstein J. Org. Chem. 2013, 9, 1730–1736, doi:10.3762/bjoc.9.199
Graphical Abstract
Scheme 1: Synthesis of substituted diethyl oxophosphonate 4.
Scheme 2: Synthesis of substituted diethyl aminophosphonate 7.
Scheme 3: Synthesis of fused diazaphospholo-substituted compounds 10a, 10b.
Scheme 4: Synthesis of fused imidazophosphono-substituted compound 13.
Scheme 5: Synthesis of β-enaminobisphosphonate 15.
Scheme 6: Synthesis of fused imidazophosphono-substituted compounds 17 and 19.
Scheme 7: Isomeric forms of diethyl 2-methylallylphosphonate (18).
Figure 1: Percentage inhibition of granuloma for the tested compounds at a dose of 50 mg per kilogram body we...